This study analyzes structural brain network changes in bipolar disorder, finding widespread connectivity disruptions linked to illness severity and medication use.

Biological Psychiatry · May 5, 2026Peer-reviewedNeuroscience

Shared genetic architecture of brain age gap across 30 cohorts worldwide

Vilte Baltramonaityte, Philippe Jawinski, Marlene Staginnus, Mina Shahisavandi, Boglarka Zsofia Kovacs, Isabel K. Schuurmans, Constantinos A. Constantinides, Ahmad R. Hariri, Alexander Teumer, Amanda Rodrigue, Ami Tsuchida, Amirhossein Manzouri, Andriana Karuk, Anna Elisabeth Fürtjes, Annalisa Lella, , Laura K. M. Han

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

medRxiv · Dec 27, 2025 · PreprintGenetic & Genomic Medicine

A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Díaz Zuluaga, Anders Martin Dale, Andriana Karuk, Annabella Di Giorgio, Benson Mwangi, Boris A. Gutman, Bronwyn J. Overs, Carlos López‐Jaramillo, Colm McDonald, Dan Joseph Stein, Dara M. Cannon, , for the ENIGMA Bipolar Disorder Working Group

The paper introduces a scalable toolkit for 3D surface-based brain analysis, demonstrating its utility in mapping subcortical shape variations across 21 international samples.

Lecture notes in computer science · Oct 4, 2025Peer-reviewedNeuroscience

Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group

Delaina B. Cimmino, Brinley N. Zabriskie, Steven G. Luke, Boris A. Gutman, Dmitry Isaev, Kathryn I. Alpert, David C. Glahn, Amanda Rodrigue, Sinead Kelly, Godfrey D. Pearlson, Vince D. Calhoun, Stefan Ehrlich, Ole A. Andreassen, Diana Tordesillas‐Gutiérrez, Benedicto Crespo‐Facorro, , Derin J. Cobia

bioRxiv · Oct 24, 2024 · PreprintNeuroscience

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

Foivos Georgiadis, Sara Larivière, David C. Glahn, Liyi Elliot Hong, Peter V Kochunov, Bryan J. Mowry, Carmel Maree Loughland, Christos Pantelis, Frans Alexander Henskens, Melissa J. Green, Murray J. Cairns, Patricia Therese Michie, Paul E. Rasser, Stanley Victor Catts, Paul A. Tooney, , Matthias Kirschner

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Molecular Psychiatry · Feb 9, 2024Peer-reviewedNeuroscience

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

Wolfgang Omlor, Finn Rabe, Simon Fuchs, Giacomo Cecere, Stephanie Homan, Werner Surbeck, Nils Kallen, Foivos Georgiadis, Tobias R. Spiller, Erich Seifritz, Thomas Wesley Weickert, Jason M. Bruggemann, Cynthia Shannon Weickert, Steven G. Potkin, Ryota Hashimoto, , Philipp Homan

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

bioRxiv · Sep 22, 2023 · PreprintNeuroscience