Author

Zhiming Chen

First Affiliated Hospital of University of South ChinaORCID 0000-0002-2423-101XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Peiliu Xu· 3 shared Sandra L. SchmidiD· 3 shared Xiangying WeiiD· 3 shared Lu HaniD· 2 shared Ziyan YangiD· 2 shared Ailing LiuiD· 1 shared Changsong Yang· 1 shared Danling Wang· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

Peiliu Xu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The U6 snRNA capping enzyme Amus/MePCE is required for the stability of U6atac and the processing of introns with features of both major and minor classes

Qiu Peng, Ying Xiao, Xiaolong Wu, Shasha Wang, qianqian liu, GONG Juan, jiyong liu, min cui, Zhiming Chen, Yikang S. Rong

The paper identifies a role for Amus/MePCE in stabilizing U6atac and shows that some minor introns require both major and minor splicing pathways for processing.

bioRxiv · Oct 24, 2026 · PreprintGenetics

eRNAformer enables genome-wide de novo mapping of enhancer-derived RNA loci

Hua Yu, W C Li, W C Li, Yunjie Liu, Yuehua Chen, Xinwen Zhang, Siyue He, Zhiming Chen, Huiquan Wang, Jiajun Ni, Tingwei Gao, Feng Li, Lu Lu

eRNAformer maps enhancer-derived RNA loci genome-wide using deep learning, identifying new eRNA loci linked to disease risk and cancer therapy.

bioRxiv · Jun 29, 2026 · PreprintBioinformatics

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

Ailing Liu, Yueping Li, Zheng Huang, Wenxing Chen, Peiliu Xu, Xiangying Wei, Guosheng Hu, Shuangquan Liu, Xiaoxia Liu, Yan He, Danling Wang, Sandra L. Schmid, Zhiming Chen

This study shows that VAMP8 depletion impairs clathrin-mediated endocytosis by disrupting endocytic cargo recycling and rerouting it to lysosomal degradation.

Proceedings of the National Academy of Sciences · Mar 26, 2026Peer-reviewedCell Biology

Dynamic early recruitment of GAK-Hsc70 regulates coated pit maturation

Zhangping He, Peiyao Zuo, Peiliu Xu, Haozhi Yuan, Madhura Bhave, Xiangying Wei, Ziyan Yang, Lu Han, Sandra L. Schmid, Zhiming Chen

This study shows that GAK-Hsc70 early recruitment promotes CCP stabilization and curvature development during clathrin-mediated endocytosis.

Proceedings of the National Academy of Sciences · May 27, 2025Peer-reviewedCell Biology

CCDC32 stabilizes clathrin-coated pits and drives their invagination

Ziyan Yang, Changsong Yang, Zheng Huang, Peiliu Xu, Yueping Li, Lu Han, Linyuan Peng, Xiangying Wei, John E. Pak, Tatyana Svitkina, Sandra L. Schmid, Zhiming Chen

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

bioRxiv · Jun 26, 2024Cell Biology