Marco Demaria

The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.

This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.

This study shows that calorie restriction induces daily torpor in mice, causing DNA damage that is repaired during arousal, and that cooling during arousal inhibits DNA repair.

This paper validates the reproducibility and utility of the p16-3MR mouse model for studying senescent cells across various conditions and discusses its strengths and limitations.

This study shows CDK4/6 inhibitors induce senescence-like changes in breast cancer cells, increasing their sensitivity to lysosomotropic agents, and suggests sequential treatment could improve therapy efficacy.

The paper identifies a novel Cdkn2a-positive tumor-associated macrophage population in brain tumors using scRNA-seq data, linking it to poor prognosis in glioblastoma.