Author

M. Grotz

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-8432-6045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:Bayesian inference· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Kilian SchoberiD· 3 shared Benjamin SchubertiD· 2 shared Bernd M. Spriewald· 2 shared Christian BogdaniD· 2 shared Felix DrostiD· 2 shared Abel Mekonnen TesfayeiD· 1 shared Aline BözeciD· 1 shared Andrea Debus· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Kilian SchoberORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

Nikolaj Pagh Kristensen, Thanos Tsaktanis, Sina Frischholz, Jasim Kada Benotmane, Lucia Klotz, Philipp Hilgendorf, M. Grotz, Mariana Sousa, Lasse Frank Voss, Stefan Schattgen, Vanessa Lang, Hannah Reimann, Cosima Storr, Roland Lang, Bernd M. Spriewald, , Kilian Schober

The paper identifies an EBV-specific T cell program in MS patients that contributes to CNS autoimmunity through B cell and myeloid cell activation.

bioRxiv · Oct 1, 2026 · PreprintImmunology

DextraDemixer enables accurate identification of antigen-specific T cells from pMHC multimer experiments

洋一岸, Felix Drost, Irene Bonafonte-Pardàs, M. Grotz, Kilian Schober, Benjamin Schubert

DextraDemixer improves identification of antigen-specific T cells from pMHC multimer data by using a Bayesian model and dynamic thresholding to reduce false discoveries.

bioRxiv · Jun 25, 2026 · PreprintBioinformatics

Quality of vaccination-induced T cell responses is conveyed by polyclonality and high, but not maximum, antigen receptor avidity

Katharina Kocher, Felix Drost, Abel Mekonnen Tesfaye, Carolin Moosmann, Christine Schülein, Myriam Grotz, Elvira D’Ippolito, Frederik Graw, Bernd M. Spriewald, Dirk Hans Busch, Christian Bogdan, Matthias Tenbusch, Benjamin Schubert, Kilian Schober

The paper analyzes T cell responses to mRNA vaccination, finding that polyclonality and high, but not maximum, antigen receptor avidity correlate with response quality.

Science Immunology · Oct 3, 2025Peer-reviewedImmunology

Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response

Baplu Rai, David Barinberg, Chunguang Liang, Andrea Debus, Manfred Rauh, Sinan Kirici, Heidi Sebald, Myriam Grotz, Tobias Gold, Meik Kunz, Aline Bözec, Jochen Mattner, Sigrid C. Roberts, Ingeborg Becker, Christian Bogdan, Ulrike Schleicher

Oral L-arginine therapy prevents and cures arginase 1-dependent chronic cutaneous leishmaniasis by restoring arginine levels and shifting the T helper cell response.

bioRxiv · Sep 23, 2025 · PreprintImmunology