Maria C. Tanzer

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

Differential cell survival outcomes in response to diverseamino acid stress

The paper investigates how different amino acid stresses affect cell survival in murine ES cells, revealing distinct survival strategies and cell death mechanisms.

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

AlphaViz: Visualization and validation of critical proteomics data directly at the raw data level

AlphaViz validates proteomics results by visualizing raw data and comparing with automated analysis outputs.

The structural context of PTMs at a proteome wide scale

The paper determines the structural context of PTMs across the human proteome and identifies regulatory sites by analyzing their distribution in folded and disordered regions.

Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

This study uses phosphoproteomics to identify CDKs' role in TNF signaling, revealing their importance in cytokine production and cell death prevention.

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

The paper develops a DIA-based workflow for ubiquitinome analysis, revealing circadian regulation through novel ubiquitination sites and clusters.