Di Hu

This study shows that deficiency of MANF worsens acute pancreatitis in mice, with sex-specific effects on inflammation and oxidative stress.

This study shows that MANF levels decline with age in mice and that MANF deficiency affects neurobehavioral functions differently in males and females.

This study develops a decoy peptide, CS2, that disrupts the ClpP-αSynuclein interaction, reducing neuropathology in Parkinson's disease models.

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.