The paper identifies CXCL1-CXCR2 signaling as a mediator of leptomeningeal metastasis resistance to radiation therapy and presents it as a potential therapeutic target.

DOI 10.1101/2025.02.20.639389

mouseproteomics

𝕏 PostBluesky

GenomicsbioRxivPreprintApr 28, 2017

Intragenomic Redistribution Of Host Transcription Factor Binding With Toxoplasma gondii Infection

Netha Ulahannan, Masako Suzuki, Claudia Avello Simões‐Pires…·John M. Greally

This study investigates how Toxoplasma gondii infection alters host transcriptional regulation by redistributing AP-1 transcription factor binding, leading to changes in chromatin accessibility and gene expression.

DOI 10.1101/132076

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsEpigenetics & ChromatinPeer-reviewedNov 16, 2015

RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships

Julie Nadel, Rodoniki Athanasiadou, Christophe Lemetre…·John M. Greally

The paper identifies RNA:DNA hybrids in the human genome, showing they are purine-rich, associated with hypomethylation and heterochromatin domains, and bound by ILF2/ILF3 transcription factors.

DOI 10.1186/s13072-015-0040-6

humanDNA methylation

𝕏 PostBluesky