Gangqi Wang

COAST aligns consecutive tissue sections using only spatial images, enabling unified multi-modal molecular data analysis without molecular markers or annotations.

The paper uses spatial metabolomics and transcriptomics to identify persistent metabolic failure in kidney niches after ischemia-reperfusion injury, highlighting mitochondrial dysfunction in otherwise healthy areas.

This study introduces Stereo-meta-seq to integrate spatial metabolomics and transcriptomics in human kidney development, revealing DHA's role in proximal tubule maturation.

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

SPCoral integrates spatial multi-omics data across different modalities and technologies, improving spatial domain identification and cross-modal analysis.

This paper introduces a quantitative MSI workflow using 13C-labeled yeast extract to enable reliable spatial metabolomics, revealing metabolic changes in the ipsilateral cortex after stroke.

This study reveals that TCA cycle rewiring at implantation supports histone acetylation programming and pluripotency transitions in mouse embryos.