Poonkuzhali Balasubramanian

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

Precise modelling and correction of a spectrum of β-thalassemic mutations in human erythroid cells by base editors

This study demonstrates the use of base editors to precisely correct various β-thalassemic mutations in human erythroid cells, showing efficient and scarless mutation correction with normal hemoglobin variants.

Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin

This study uses CRISPR base editing to identify novel mutations in the HBG promoter that increase fetal hemoglobin expression without harmful effects.