Saulius Sumanas

The paper maps gene regulators of endothelial cell differentiation using CRISPR and single-cell RNA-seq, identifying Hippo mechanosignaling as critical for endothelial identity.

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

This study identifies Jam2 signaling and Hand2 function as essential for forming organ-specific vascular progenitors in zebrafish embryos, with implications for evolutionary conservation.

This paper develops zebrafish hand2 Cre and CreERT2 drivers using CRISPR-Cas9 to label mesodermal and ectodermal lineages, revealing lineage contributions to various tissues and vasculature.

This study shows that SHE and ABL signaling regulate vascular lumen size in zebrafish and human endothelial cells by modulating claudin expression and cell proliferation.

The paper identifies a novel site of late vasculogenesis in zebrafish embryos that contributes to functional blood vessels after circulation is established.

The paper performs single-cell RNA-seq on zebrafish embryos to identify 27 cell types and subtypes in the trunk region, providing a resource for developmental biology research.