This study uses mesoscale calcium imaging in HD mice during a sensory-guided task to explore altered cortical activity and its behavioral implications.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience

Effect of chronic upregulation of endocannabinoid signaling in vivo with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease mice

Marja D. Sepers, Cameron L. Woodard, Daniel Ramandi, Haley A. Vecchiarelli, Matthew N. Hill, Lynn A. Raymond

This study shows that JZL184 improves motor learning and striatal plasticity in YAC128 HD mice by increasing 2-AG levels, suggesting endocannabinoid modulation as a potential therapeutic target for HD.

bioRxiv · Sep 25, 2024 · PreprintNeuroscience

Activin A targets extrasynaptic NMDA receptors to improve neuronal and behavioral deficits in a mouse model of Huntington disease

Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Yin Oh, James P. Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond

bioRxiv · Sep 6, 2023 · PreprintNeuroscience

Altered cortical processing of sensory input in Huntington disease mouse models

Marja D. Sepers, James P. Mackay, Ellen T. Koch, Dongsheng Xiao, Majid H. Mohajerani, Allen W. Chan, Amy Smith-Dijak, Daniel Ramandi, Timothy H. Murphy, Lynn A. Raymond

This study examines altered cortical processing of sensory input in Huntington disease mouse models, finding increased LFP power and sensory signal spread in HD mice.

Neurobiology of Disease · Apr 20, 2022Peer-reviewedNeuroscience