Marja D. Sepers

Effect of chronic upregulation of endocannabinoid signaling in vivo with JZL184 on striatal synaptic plasticity and motor learning in YAC128 Huntington disease mice

This study shows that JZL184 improves motor learning and striatal plasticity in YAC128 HD mice by increasing 2-AG levels, suggesting endocannabinoid modulation as a potential therapeutic target for HD.

Activin A targets extrasynaptic NMDA receptors to improve neuronal and behavioral deficits in a mouse model of Huntington disease

Longitudinal assessment of water-reaching reveals altered cortical activity and fine motor coordination defects in a Huntington Disease model

This study uses a water-reaching task to identify early forelimb motor deficits and cortical activity changes in Huntington Disease mouse models.

Altered cortical processing of sensory input in Huntington disease mouse models

This study examines altered cortical processing of sensory input in Huntington disease mouse models, finding increased LFP power and sensory signal spread in HD mice.

Impaired refinement of kinematic variability in Huntington disease mice on an automated home-cage forelimb motor task

This paper introduces an automated behavioural testing system to assess motor learning in Huntington disease mice and identifies impaired kinematic variability modulation as a specific deficit.

Regulation of Hippocampal Excitatory Synapses by the Zdhhc5 Palmitoyl Acyl Transferase

This study shows Zdhhc5 is essential for forming excitatory synapses and its loss leads to synaptic deficits in mice.