Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function
Anne Bremer, Walter H. Lang, Ryan P. Kempen, Kumari Sweta, Aaron B. Taylor, Madeleine B. Borgia, Aseem Z. Ansari, Tanja Mittag
This study compares two models of transcription factor function in yeast, showing that Gcn4 can act through both soluble complexes and condensates, with DNA binding suppressing phase separation.
Molecular Cell · Jul 1, 2025Peer-reviewedBiophysics