Synthetic BiologybioRxivPreprint
Nanobody-Functionalized AAV achieves Promoter-independent Neuronal Targeting in the CNS
Ajay Extross, Ezequiel Marrón Fernández de Velasco, Yungui He…·Daniel Schmidt
This paper develops AAV-m5, a nanobody-functionalized AAV vector that targets neurons via mGluR5, achieving efficient and specific transduction in the CNS without relying on promoters.
DOI 10.64898/2026.09.18.752817