Author

Toshiyuki Araki

NYU Langone’s Laura and Isaac Perlmutter Cancer CenterORCID 0000-0002-1179-4534Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Benjamin G. NeeliD· 1 shared Cameron Genxuan LianiD· 1 shared Daniel Pushparaju Yeggoni· 1 shared Daniëlle T.J. WouterseniD· 1 shared Eli RothenbergiD· 1 shared Heidi StuhlmanniD· 1 shared Hiep L.D. Nguyen· 1 shared Jeroen den HertogiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Benjamin G. NeelORCID

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1 paper

Recent·Most cited

SHP2 binds directly to SOS1 to enable RAS activation

Toshiyuki Araki, Yashika Agrawal, Sachin S. Katti, Hiep L.D. Nguyen, Daniel Pushparaju Yeggoni, Mitchell J. Geer, Wei Wei, Daniëlle T.J. Woutersen, Tieme Bijlsma, Cameron Genxuan Lian, Natalie M. Clark, Namrata D. Udeshi, Steven A. Carr, Heidi Stuhlmann, Michael A. Davies, , Wolfgang Peti

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

bioRxiv · Jun 13, 2026 · PreprintCancer Biology