This study identifies miRNA signatures associated with resilience to Alzheimer's disease, revealing potential therapeutic targets for neuroprotection.

bioRxiv · Aug 10, 2026 · PreprintNeuroscience

Thalamo-accumbal circuit adaptations following extended oxycodone abstinence.

Yanaira Alonso‐Caraballo, Yan Li, Nicholas J. Constantino, Megan A Neal, Gillian S. Driscoll, Yunona Manasian, Grace K Cai, Maria Mavrikaki, Vadim Y. Bolshakov, Elena H. Chartoff

This study examines sex differences in relapse vulnerability after oxycodone abstinence by analyzing neural circuit adaptations in the thalamo-accumbal pathway in male and female rats.

eLife · Aug 4, 2026Peer-reviewedNeuroscience

A microRNA atlas of the human prefrontal cortex across the adult lifespan

Irais E. Valenzuela-Arzeta, Pourya Naderi Yeganeh, Anupama Rai, Jane Banahan, Artemis Iatrou, Leinal Sejour, Madison M. Uyemura, Isaac H. Solomon, Nikolaos P. Daskalakis, Ioannis Vlachos, Winston Hide, Frank John Slack, Maria Mavrikaki

The paper creates a miRNA atlas of the human prefrontal cortex across aging, identifying age-related miRNA changes and highlighting miR-34a-5p as a key upregulated miRNA in older individuals.

bioRxiv · May 28, 2026 · PreprintNeuroscience

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex

Anupama Rai, Artemis Iatrou, Irais E. Valenzuela-Arzeta, Alexandra L. Bartlett, Jane Banahan, Vedant Desai, Lorena Pantano, Isabel Castanho, Pourya Naderi Yeganeh, Athanasios Ploumakis, Shuoshuo Wang, Antonella Arruda de amaral, Nikolaos Kalavros, Sheethal Umesh Nagalakshmi, Peter Tsvetkov, , Maria Mavrikaki

The paper performs spatial transcriptomics on the human prefrontal cortex across the lifespan to identify aging-related changes in different cortical layers.

bioRxiv · Jan 12, 2026 · PreprintNeuroscience