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Genedex: Contextualizing gene signatures across Alzheimer's disease pathology, cell types, and brain regions

Genedex integrates gene signatures from Alzheimer's disease studies to contextualize gene expression across pathology, cell types, and brain regions, revealing new insights into disease mechanisms.

MicroRNA correlates of resilience to Alzheimer's disease identify candidate therapeutic targets for neuroprotection

This study identifies miRNA signatures associated with resilience to Alzheimer's disease, revealing potential therapeutic targets for neuroprotection.

Systemic infections alter cortical transcriptional signatures in Alzheimer's disease

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

A microRNA atlas of the human prefrontal cortex across the adult lifespan

The paper creates a miRNA atlas of the human prefrontal cortex across aging, identifying age-related miRNA changes and highlighting miR-34a-5p as a key upregulated miRNA in older individuals.

Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer's Disease-Associated Genes in the Hispanic Population

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex

The paper performs spatial transcriptomics on the human prefrontal cortex across the lifespan to identify aging-related changes in different cortical layers.

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease

This study identifies molecular and cellular signatures of cognitive resilience in Alzheimer's disease by integrating multi-omics data from brain tissues.

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2

This study identifies two novel Alzheimer's disease-associated genes, DTNB and DLG2, by analyzing rare variants in whole-genome sequencing data from AD family datasets.

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Coexpression meta-analysis of 2114 human brain RNA-seq samples across the AMP-AD consortium identifies five consensus Alzheimer's disease transcriptional clusters, including two sex-heterogeneous clusters and a previously unreported proteostasis cluster.

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

Project MinE analyzes whole-genome sequencing data from ALS patients and controls to study genetic variation and its implications for disease susceptibility.