Minsi Zhang

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

GuideScan2 constructs high-specificity CRISPR gRNA databases and enables design of allele-specific gRNAs, reducing off-target effects in gene essentiality screens.

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.