Claire Wyart

Unraveling phenotypic variation in multiscale behavioral dynamics

Comparing coarse-grained dynamics across resolutions, weighted by sampling uncertainty, yields phenotypic spaces linking E. coli run speed to CheB and showing paramecia experience narrows zebrafish variability.

Whole brain mapping of spinal-projecting neurons in larval zebrafish

Two-photon optical backfills of pan-neuronal photoactivatable GFP in larval zebrafish yield an estimated 1,300 spinal-projecting neurons per larva across hindbrain, midbrain and diencephalon, with tentative homologies to mammalian nuclei.

Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord

The paper identifies chemoreceptors in cerebrospinal fluid-contacting neurons and neighboring cells, revealing multiple chemosensory pathways for detecting glutamate, somatostatin, and LDL in the cerebrospinal fluid.

Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass

The paper shows that larval zebrafish encode flow direction relative to their center-of-mass in the hindbrain, enabling motor responses to fluid motion.

Noradrenaline prolongs the state of motor arrest via cerebrospinal fluid signaling

This study shows noradrenaline prolongs motor arrest through cerebrospinal fluid signaling via Adra1a receptors on ependymal radial glia.

Body-segment coordination as a new predictor of freezing of gait in people with Parkinson disease

The paper identifies body-segment coordination as a predictor of postoperative freezing of gait severity in Parkinson's disease patients using kinematic data and LASSO regression.

Uncovering multiscale structure in the variability of larval zebrafish navigation

The paper develops a method to analyze behavioral variability in larval zebrafish by identifying motor strategies and their transitions across different environmental cues.

Norepinephrine changes behavioral state via astroglial purinergic signaling

The paper shows norepinephrine induces astroglial purinergic signaling that suppresses behavior through adenosine receptor activation in zebrafish.

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

This study generates Sspo knockout mice and finds reduced brain ventricle size but only minor spine curvature defects.

Functional coupling of the mesencephalic locomotor region and V2a reticulospinal neurons driving forward locomotion

This study identifies the mesencephalic locomotor region's role in recruiting V2a reticulospinal neurons to control forward locomotion in zebrafish.

Granger causality analysis for calcium transients in neuronal networks: challenges and improvements

This paper improves Granger causality analysis for calcium imaging data to better infer information flow in neuronal networks.

Lateral line hair cells integrate mechanical and chemical cues to orient navigation

This study shows zebrafish lateral line hair cells detect serotonin, influencing navigation behavior in response to environmental cues.

Evolutionary divergence of locomotion in two related vertebrate species

This study compares swimming patterns and neuronal circuits in two closely related fish species to understand how environmental factors drive evolutionary divergence in locomotion.

Spinal sensory neurons project onto hindbrain to stabilize posture and enhance locomotor speed

This paper identifies that rostral spinal sensory neurons synapse onto hindbrain motor neurons and reticulospinal neurons, enhancing locomotor speed and postural control.

Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

The paper shows the Reissner fiber regulates CSF-cNs via urp2 and calcium signaling, and adrenergic activation can substitute its function in zebrafish embryos.

A calibrated optogenetic toolbox of stable zebrafish opsin lines

The paper develops and calibrates nine zebrafish opsin lines for reliable in vivo optogenetic control of neural activity.

Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo

The paper shows that Reissner fiber is critical for CSF-contacting neurons to detect spinal curvature in zebrafish larvae.

Simultaneous fluorescence imaging of tilted focal planes at two depths in thick neural tissue: Implementation with remote focus in a widefield electrophysiological microscope.

Multiplexed temporally focused light shaping for high-resolutionmulti-cell targeting

The paper introduces a method for high-resolution multi-cell optogenetic targeting using temporally focused light shaping in Drosophila and zebrafish larvae.

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

This study identifies Pkd2l1 as essential for mechanosensation in cerebrospinal fluid-contacting neurons and spine curvature maintenance in zebrafish.