Jiyang Zhang

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

An engineered EGFR-targeting DARPin selectively inhibits ovulation through extracellular receptor blockade and establishes a versatile platform for investigating ovarian signaling and reproductive disorders.

This study shows that inhibiting JNK in oocytes protects against chemotherapy-induced infertility and ovarian hormone loss in mice.

This study investigates the effects of long- and short-chain PFAS on ovarian function in mice, finding that long-chain PFAS disrupt follicle maturation and ovulation via PPARγ activation.

This study investigates the dose-response effects of FSH on mouse folliculogenesis using single-cell RNA sequencing, revealing gene expression patterns and potential molecular mechanisms of FSH-induced ovarian disorders.