A Designed Ankyrin Repeat Protein (DARPin) Targeting EGFR Inhibits Ovulation and Enables a Novel Platform for Studying Ovarian Biology and Pathophysiology
Yubing Liu, Jiyang Zhang, Shichao Liu, Connie Mitra, Yue Liu, Hannah M. VanBenschoten, Brittany A. Goods, Feng Chen, Shuo Xiao
An engineered EGFR-targeting DARPin selectively inhibits ovulation through extracellular receptor blockade and establishes a versatile platform for investigating ovarian signaling and reproductive disorders.
bioRxiv · Jun 26, 2026 · PreprintPharmacology & Toxicology