Nigel A. Turner

CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN)

The paper shows CD38 mediates base exchange on NMN to produce NaMN, linking salvage and de novo NAD+ pathways.

Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma

This study identifies de novo lipogenesis as a mechanism of gemcitabine resistance in PDAC and shows that targeting lipid synthesis enzymes enhances treatment efficacy.

Ancestral dietary change alters development of Drosophila larvae through MAPK signalling

This study shows ancestral diet alters Drosophila larval development timing via MAPK signaling pathway changes.

Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65)

This study shows NEGR1 promotes synaptic targeting of GAD65, affecting GABAergic signaling and feeding behavior in mice.

NAD+ repletion rescues female fertility during reproductive ageing

This study shows that NAD+ repletion with NMN improves oocyte quality and fertility in aged animals, and enhances IVF success in older mice.

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.