Author

Renae M. Ryan

The University of SydneyORCID 0000-0002-8680-4610Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Emad TajkhorshidiD· 2 shared Qianyi WuiD· 2 shared Shashank PantiD· 2 shared Alastair Garner· 1 shared Alexandra C. SchwartziD· 1 shared Amanda M. DuraniD· 1 shared Andrea N. Belovich· 1 shared Angela M. CarteriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Emad TajkhorshidORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

One high-order ion-coupling mechanism generates multiple SLC1A stoichiometries

Renae M Ryan, Qianyi Wu, Yan Jiang, Chelsea Briot, Ashkan Fakharzadeh, Morgan M Dooley, Shashank Pant, Hariprasad Venugopal, Krishna D Reddy, Emad Tajkhorshid

This study identifies a high-order ion-coupling mechanism in EAAT transporters by showing that dEAAT2 can acquire Na+, H+, and K+ dependence through mutations, mimicking human hEAAT2's complex ion coupling.

bioRxiv · Nov 10, 2026 · PreprintBiophysics

Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

Qianyi Wu, Azman Akhter, Shashank Pant, Eunjoo Cho, Jin Xin Zhu, Alastair Garner, Tomoko Ohyama, Emad Tajkhorshid, Donald J. van Meyel, Renae M. Ryan

The paper investigates how mutations in SLC1A3 (hEAAT1) affect chloride channel activity and glutamate transport in glial cells, linking these changes to the pathology of episodic ataxia type 6.

Journal of Clinical Investigation · Feb 15, 2022Peer-reviewedNeuroscience

Psychomotor impairments and therapeutic implications revealed by a mutation linked with Infantile Parkinsonism-Dystonia

Jenny I. Aguilar, Mary Hongying Cheng, Josep S. Font, Alexandra C. Schwartz, Kaitlyn V. Ledwitch, Amanda M. Duran, Samuel J. Mabry, Andrea N. Belovich, Yanqi Zhu, Angela M. Carter, Lei Shi, Manju A. Kurian, Cristina Fenollar‐Ferrer, Jens Meiler, Renae M. Ryan, , Aurelio Galli

This study investigates the effects of a DAT mutation linked to DTDS, showing impaired dopamine function and behavioral deficits in Drosophila, with potential therapeutic implications.

eLife · May 17, 2021Peer-reviewedNeuroscience