Author

Olivier Rousseau

Concordia UniversityORCID 0000-0002-8691-2048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Björn D. M. BeaniD· 2 shared Malcolm S. WhitewayiD· 2 shared Vincent J. J. MartiniD· 2 shared Andrew D. EllingtoniD· 1 shared Brendan M. FloydiD· 1 shared Chang C. LiuiD· 1 shared Christien DykstraiD· 1 shared Colleen J. MulvihilliD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Björn D. M. BeanORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 2, 2026

Heterologous engineering of receptors using OrthoRep (HERO) for directed evolution of GPCRs in yeast

Christien Dykstra, Björn D. M. Bean, Olivier Rousseau…·Vincent J. J. Martin

The paper improves GPCR biosensors in yeast using a new platform called HERO, achieving significant sensitivity gains through directed evolution.

DOI 10.64898/2026.09.30.755785

yeastproteomics

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Synthetic BiologyNature CommunicationsPeer-reviewedMay 24, 2022

Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols

Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge…·Vincent J. J. Martin

This study engineers yeast to produce cholesterol, enabling functional expression of human opioid and other GPCRs, creating biosensors with measurable agonist responses and antagonist inhibition.

26 citations

yeastexperimental assay

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