Molecular BiologyThe CRISPR JournalPeer-reviewed
Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides
Thomas Swartjes, Peng Shang, Dennis T.M. van den Berg…·Richard A. Notebaart
This study shows DNA oligonucleotides can inhibit Cas9 activity in human cells and in vitro by targeting the guide RNA and requiring a PAM-loop for effective inhibition.
DOI 10.1089/crispr.2022.0011