Richard A. Notebaart

The paper maps enzyme activation networks in yeast, revealing widespread regulatory crosstalk between metabolic pathways and highlighting the role of essential metabolites in metabolic plasticity.

The paper uses dynamic flux balance analysis to identify conserved and strain-specific metabolic mechanisms in Saccharomyces cerevisiae that influence ester formation during alcoholic fermentation.

This study shows DNA oligonucleotides can inhibit Cas9 activity in human cells and in vitro by targeting the guide RNA and requiring a PAM-loop for effective inhibition.

This study shows that enzyme promiscuity enables E. coli to adapt to novel substrates through computational modeling and lab evolution experiments.