TiSAM improves whole-slide image segmentation by fusing spatial and histopathology features, achieving high accuracy across diverse datasets and scanners.

bioRxiv · Oct 19, 2026 · PreprintBioinformatics

Senescence and DNA Damage-Induced Inflammation Drive Heart Failure with Preserved Ejection Fraction in Cardiovascular Kidney Metabolic Syndrome

Dao‐Fu Dai, Jun‐yi Zhu, Meng Qiu Gao, Kaihao Wang, Nastaran Daneshgar, Xiaoping Yang, Virginia Shalkey Hahn, Monica Vladut Talor, Daniela Čiháková, Avi Z. Rosenberg, Antentor Othrell Hinton Jr., Zhe Han

This study identifies DNA damage-driven senescence and ZBP1-cGAS-STING signaling as conserved mechanisms linking cardiovascular-kidney-metabolic comorbidities to HFpEF.

bioRxiv · Apr 16, 2026 · PreprintPathology

Identification of a Highly Functional Effector CD8+ T Cell Program After Transplantation in Mice and Humans

Riley P. Leathem, Joel S. Freibaum, Gregory S. Cohen, Robin A. Welsh, Yukai Tang, Marina Willson Shirkey, Sanniddhya B. Bardhan, Ryo Hatano, Chikao Morimoto, Byoung Chol Oh, Daniela Čiháková, Jonathan S. Bromberg, Scott M. Krummey

This study identifies a functional effector CD8+ T cell program in mice and humans that persists into memory after antigen clearance, driven by CD43 1B11 expression.

American Journal of Transplantation · Feb 21, 2026Peer-reviewedImmunology