Liyun Miao

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

The paper investigates how Lamin A/C influences chromatin structure during early mammalian lineage segregation, showing its role in maintaining trophectoderm identity.

Novel cell states arise in embryonic cells devoid of key reprogramming factors

The paper investigates the developmental fate of zebrafish embryos lacking the reprogramming factors Nanog, Pou5f3, and Sox19b, finding that cells can acquire novel cell states or primordial germ cell-like states.

Genetically encoded affinity reagents (GEARs): A toolkit for visualizing and manipulating endogenous protein function in vivo.

This paper introduces GEARs, a toolkit for visualizing and manipulating endogenous proteins in vivo, demonstrating its use with Nanog and Vangl2 in zebrafish.

linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells

The paper identifies two micropeptides encoded by lincRNAs that regulate chromatin accessibility in vertebrate-specific neural cells and show their role in brain development.

Synergistic activity of Nanog, Pou5f3, and Sox19b establishes chromatin accessibility and developmental competence in a context-dependent manner

This study shows that Nanog, Pou5f3, and Sox19b work together in a context-dependent way to establish chromatin accessibility and developmental competence in zebrafish embryos.

Brd4 and P300 regulate zygotic genome activation through histone acetylation

This study shows that Brd4 and P300 regulate zygotic genome activation through histone acetylation in zebrafish embryos.

RES complex is associated with intron definition and required for zebrafish early embryogenesis

The study shows the RES complex is essential for zebrafish early development and intron splicing, with specific intronic features associated with its activity.