Juan P. Romero

Characterization of immune cell populations in the tumor microenvironment of colorectal cancer using high definition spatial profiling

This study uses Visium HD spatial transcriptomics to map immune cell populations in colorectal cancer tumor microenvironments, identifying spatially distinct macrophage and T cell subpopulations.

Unravelling the molecular activation of the reparative cardiac fibroblasts after myocardial infarction

The paper identifies molecular dynamics and a new marker, Aspn, for reparative cardiac fibroblasts in mice, pigs, and patients after myocardial infarction.

Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development

This study investigates the embryonic origin of coronary artery fistulas (CAFs) using animal models and shows that myocardial discontinuities in the ventricular wall cause CAF formation through abnormal epicardial-endocardial interactions.

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution

This study uses single-cell RNA sequencing to analyze changes in hematopoietic stem and progenitor cells during aging and myeloid malignancies, identifying altered gene expression and regulatory networks.

Comparing 10x Genomics single-cell 3' and 5' assay in short-and long-read sequencing

This study compares 10x Genomics 3' and 5' assays using short and long reads, finding differences in exonic/intronic capture and transcript completeness.

Comparison of RNA-seq and Microarray Platforms for Splice Event Detection using a Cross-Platform Algorithm

This study compares RNA-seq and junction arrays for detecting splice events using a cross-platform algorithm, finding RNA-seq superior for novel events but both coherent for known regions.