Author

I A Hughes

Boston UniversityORCID 0000-0002-8769-4011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Aldana D. GojanovichiD· 1 shared Andrés A. Quiñones-MolinaiD· 1 shared Andrew J. HendersoniD· 1 shared Gustavo MostoslavskyiD· 1 shared Hisashi AkiyamaiD· 1 shared Mengwei YangiD· 1 shared Sallieu Jalloh· 1 shared Suryaram GummuluruiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

Aldana D. GojanovichORCID

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1 paper

Recent·Most cited

MicrobiologyPLoS BiologyPeer-reviewedSep 8, 2025

Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells

Sallieu Jalloh, I A Hughes, Hisashi Akiyama…·Suryaram Gummuluru

This study shows that HIV-1 intron-containing RNA induces NLRP1 inflammasome activation and IL-1β secretion in myeloid cells through a RLR- and endosomal TLR-independent mechanism.

9 citations

humanexperimental assay