Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells
Sallieu Jalloh, I A Hughes, Hisashi Akiyama, Aldana D. Gojanovich, Andrés A. Quiñones-Molina, Mengwei Yang, Andrew J. Henderson, Gustavo Mostoslavsky, Suryaram Gummuluru
This study shows that HIV-1 intron-containing RNA induces NLRP1 inflammasome activation and IL-1β secretion in myeloid cells through a RLR- and endosomal TLR-independent mechanism.
PLoS Biology · Sep 8, 2025Peer-reviewedMicrobiology