Author

Trinayan Kashyap

Karyopharm Therapeutics (United States)ORCID 0000-0002-8784-5641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ashley B. NiesmaniD· 1 shared Bert KwanteniD· 1 shared Binita Shakya· 1 shared Brecht PermentieriD· 1 shared Casey E. WingiD· 1 shared Dirk DaelemansiD· 1 shared Ho Yee Joyce FungiD· 1 shared Joseph M. ReadyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ashley B. NiesmanORCID

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1 paper

Recent·Most cited

SINE compounds activate exportin-1 degradation via an allosteric mechanism

Casey E. Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Çağatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, , Yuh Min Chook

This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.

Nature Chemical Biology · Nov 21, 2025Peer-reviewedCancer Biology