KEAP1 retention in phase-separated p62 bodies drives liver damage in autophagy-deficient conditions
Shuhei Takada, Nozomi Shinomiya, Gaoxin Mao, Hikaru Tsuchiya, Tomoaki Koga, Satoko Komatsu‐Hirota, Yu‐shin Sou, Manabu Abe, Elena Ryzhii, Michitaka Suzuki, Mitsuyoshi Nakao, Satoshi Waguri, Hideaki Morishita, Masaaki Komatsu
The paper shows that KEAP1 retention in p62 bodies and NRF2 activation cause liver damage when autophagy is impaired, and that blocking p62-KEAP1 interactions reduces this damage.
EMBO Reports · May 28, 2025Peer-reviewedCell Biology