Mahesh Shivarama Shetty

This study shows that increasing cAMP levels in hippocampal neurons during sleep deprivation prevents deficits in long-term potentiation, indicating cAMP signaling mediates sleep loss effects on synaptic plasticity.

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.

This study shows that POPDC1 knockout mice have enhanced hippocampal long-term potentiation, suggesting POPDC1 modulates cAMP signaling in synaptic plasticity.

The paper shows that translin/trax is required for a specific form of hippocampal synaptic plasticity dependent on postsynaptic PKA, but not for presynaptic PKA-dependent plasticity.