Karl-Peter Giese

This study shows that inhibiting LSD1, a histone demethylase, restores learning and memory in aged mice by reversing age-related defects in H3K4me3 dynamics and synaptic plasticity.

This study shows that KDM5B deficiency in mice leads to autism-like behaviors and increased brain size, which can be mitigated by NMDAR antagonists.

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.

This study shows that POPDC1 knockout mice have enhanced hippocampal long-term potentiation, suggesting POPDC1 modulates cAMP signaling in synaptic plasticity.

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

The paper shows that reducing CYFIP2 in mice leads to Alzheimer's disease-like features, suggesting CYFIP2 as a therapeutic target.