Emily Nicole Walsh

This study identifies a subset of hippocampal CA1 pyramidal neurons that are selectively reactivated by repeated sleep deprivation and shows associated molecular changes.

This study investigates how different PDE4A isoforms affect cAMP-dependent long-term potentiation (LTP), finding that PDE4A5 specifically impairs TBS-LTP through its unique N-terminus.

This study uses spatial transcriptomics to show that sleep deprivation causes region-specific gene expression changes in the brain, with the hippocampus showing the most significant alterations.

This study shows that increasing cAMP levels in hippocampal neurons during sleep deprivation prevents deficits in long-term potentiation, indicating cAMP signaling mediates sleep loss effects on synaptic plasticity.

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.