ImmunologybioRxivPreprint
PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance
Shin Foong Ngiow, Ryan P. O’Connell, Sasikanth Manne…·E. John Wherry
The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.
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