Zi‐Jiang Chen

This study identifies CWF19L2 as a critical regulator of pre-mRNA alternative splicing during the maternal-to-zygotic transition, showing its necessity for female fertility.

This study shows that Tmc7 deficiency in mice causes acrosome biogenesis defects and male infertility by disrupting Golgi function and ion homeostasis.

This study identifies impaired maternal mRNA deadenylation as a molecular defect in in vitro matured mouse and human oocytes, leading to abnormal gene expression.

This study shows LSM14B is essential for MARDO assembly in mouse oocytes, leading to meiotic maturation failure and infertility.

This study shows that SSH2 is essential for acrosome biogenesis and male fertility in mice by regulating actin remodeling through COFILIN.

This study identifies CFAP53 as essential for sperm flagellum biogenesis, showing its role in male infertility and interactions with proteins in the manchette and sperm tail.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.

This study identifies ZCWPW1 as an H3K4me3 reader required for DSB repair and synapsis in mouse testes, showing its dependency on PRDM9 activity.

The paper identifies 571 noncoded amino acids in the human sperm proteome, revealing novel residues and disease associations through mass spectrometry and exon sequencing.