Fred Chang

Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope

Overexpressing mCherry-GST targeted to the nucleus or cytoplasm in fission yeast shifts the nuclear-to-cell volume ratio as a parameter-free colloid osmotic model predicts, retuning nucleoplasm diffusivity, condensates and heterochromatin.

LGBTQ+ realities in the biological sciences

This study surveys LGBTQ+ biologists to assess workplace climate and belonging, finding lower morale and exclusionary experiences among transgender and gender non-conforming scientists.

Analyses of bent spindles reveal the mechanics of anaphase B in fission yeast

The paper investigates the mechanical properties of fission yeast spindles by analyzing their response to mechanical and genetic perturbations, revealing their behavior as a rigid beam and identifying key proteins involved in elongation and structural integrity.

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast

The paper shows that intracellular diffusion in fission yeast increases with cell size, linked to changes in proteome composition and DNA-to-cytoplasm ratio.

Microtubule dynamic instability is sensitive to specific biological viscogens in vitro

This study shows that microtubule dynamic instability is sensitive to specific viscogens, with glycerol having a distinct effect compared to other viscogens.