Author

I-Lin Ho

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-8914-710XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Angela K. DeemiD· 2 shared Giulio Francesco DraettaiD· 2 shared Sanjana SrinivasaniD· 2 shared Wantong YaoiD· 2 shared Alessandro CarugoiD· 1 shared Andrea VialeiD· 1 shared Ben VanderkrukiD· 1 shared Brad G. HoffmaniD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Angela K. DeemORCID

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2 papers

Recent·Most cited

WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer

Francesca Citron, I-Lin Ho, Chiara Balestrieri, Zhaoliang Liu, Er-Yen Yen, Luca Cecchetto, Luigi Perelli, Li Zhang, Luis A Castillo, Nicholas Blazanin, Charles A. Dyke, Rutvi Shah, Sergio Attanasio, Sanjana Srinivasan, Ko‐Chien Chen, , Giulio Francesco Draetta

This study shows that disrupting the WRAD core in pancreatic cancer leads to DNA replication errors, immune response activation, and improved response to immune checkpoint inhibitors.

bioRxiv · Oct 21, 2024 · PreprintCancer Biology

Multiplexed pooled library screening with Cpf1

Jintan Liu, Sanjana Srinivasan, Chieh-Yuan Li, I-Lin Ho, Johnathon Lynn Rose, MennatAllah Shaheen, Gang Wang, Wantong Yao, Angela K. Deem, Chris Bristow, Traver Hart, Giulio Francesco Draetta

The paper develops a multiplexed CRISPR/Cas9-based screening strategy using AsCpf1 to create a smaller, more efficient genome-wide knockout library.

Nature Communications · Jul 17, 2019Peer-reviewedSystems Biology