Maralice Conacci‐Sorrell

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions

This study shows that branched actin-driven membrane protrusions (BAMPs) enhance oncogenic KRAS signaling by amplifying upstream regulators and promoting cell proliferation through merlin inactivation.

In vivo evidence for bleb-induced survival signaling in metastatic melanoma

This paper shows that bleb-induced septin signaling supports survival of metastatic melanoma cells in vivo, and disrupting this pathway reduces metastasis.

Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations

This study maps tryptophan metabolites across multiple tissues, sexes, and ages in mice, revealing significant variations in metabolism that could inform disease-targeted therapies.

Anchorage-independent cell proliferation promoted by fascin's F-actin bundling

This study identifies fascin-1's role in promoting anchorage-independent proliferation through a novel signaling complex called PASS, which drives Rac1/PAK/JNK signaling in cancer cells.

ZNF692 organizes a hub for ribosome maturation enhancing translation in rapidly proliferating cells

This study identifies ZNF692 as a nucleolar scaffold that enhances 40S ribosome maturation and translation efficiency in rapidly proliferating cells, particularly in cancer cells.