William M. Keyes

Senescent cells exhibit features of developmental signaling centres

This study identifies senescent cells as resembling developmental signaling centers by showing their SASP activates conserved developmental pathways across species.

Developmental senescence profiling reveals Eda2r as a common mediator in the core senescence program

The paper identifies Eda2r as a key mediator in both developmental and pathological senescence by profiling senescent cells in mouse limb development and comparing them to in vitro and in vivo models.

Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects

The paper investigates how aberrant p19Arf-mediated cellular senescence in neuroepithelial cells contributes to VPA-induced developmental defects in embryos.

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

The paper uses scRNA-seq and deep learning to map cell cycle gene regulation dynamics in mouse and human cells, identifying key transcription waves and transitions.