Matej Durik

The paper identifies Eda2r as a key mediator in both developmental and pathological senescence by profiling senescent cells in mouse limb development and comparing them to in vitro and in vivo models.

The paper uses scRNA-seq and deep learning to map cell cycle gene regulation dynamics in mouse and human cells, identifying key transcription waves and transitions.

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.