Matthieu Jung

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

This study shows FGF8 signaling influences regional identity and cellular diversity in human cerebral organoids, affecting neural progenitor fate and genes linked to neurodevelopmental disorders.

RNA polymerase II transcription with partially assembled TFIID complexes

This study shows that partially assembled TFIID complexes can initiate RNA polymerase II transcription but cannot fully replace holo-TFIID over time.

A time- and space-resolved nuclear receptor atlas in mouse liver

This paper maps nuclear receptor expression in mouse liver across time and space using single-cell RNAseq data.

Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

This study shows that loss of NR5A1 in Sertoli cells after sex determination leads to their transdifferentiation, anoikis, and testis abnormalities.

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

The paper uses scRNA-seq and deep learning to map cell cycle gene regulation dynamics in mouse and human cells, identifying key transcription waves and transitions.