Grace Hui Ting Yeo

Accessible spatial host-microbe profiling in tumour tissues

This paper introduces HOMES-seq, a spatial transcriptomics workflow for detecting microbes and host transcripts in colorectal tumours, improving sensitivity and reducing costs.

Systematic elucidation of genetic mechanisms underlying cholesterol uptake

This study identifies 21 genes whose rare variants affect LDL-C levels by altering cholesterol uptake, using CRISPR screening and co-essentiality analysis.

Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.

Generative modeling of single-cell population time series for inferring cell differentiation landscapes

This paper introduces PRESCIENT, a generative model for inferring cell differentiation landscapes from single-cell time-series data, showing improved prediction of cell fate and perturbation responses.