Author

Maggie Chen

Brigham and Women's HospitalORCID 0000-0002-1900-1017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Benyapa KhowpinitchaiiD· 1 shared Callie J. DonahueiD· 1 shared Christopher A. CassaiD· 1 shared Dawen CaiiD· 1 shared Douglas H. RoossieniD· 1 shared Erica M. Edwards· 1 shared Ersin AkıncıiD· 1 shared Fatema AbdurrobiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperGenetics

Benyapa KhowpinitchaiORCID

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3 papers

Recent·Most cited

Bitbow: a digital format of Brainbow enables highly efficient neuronal lineage tracing and morphology reconstruction in single brains

Ye Li, Logan A. Walker, Yimeng Zhao, Erica M. Edwards, Sylvia N. Michki, Hon Pong Jimmy Cheng, Marya Ghazzi, Tiffany Y Chen, Maggie Chen, Douglas H. Roossien, Dawen Cai

Frontiers in Neural Circuits · Oct 20, 2021Peer-reviewedNeuroscience

Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

Ersin Akıncı, Minsun Cha, Lin Lin, Grace Hui Ting Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa Cardoso Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Ky Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, , Richard I. Sherwood

This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.

bioRxiv · Aug 27, 2020 · PreprintGenetics

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions

Zhuyu Peng, Wen‐Chin Huang, Maggie Chen, Jay Penney, Hugh P. Cam, Fatema Abdurrob, Leyla Anne Akay, Xiao Chen, William T. Ralvenius, Lorena Pantano, Li‐Huei Tsai

This study investigates the role of Cdk5 in microglia under physiological and pathological conditions, finding transcriptional changes but minimal effects on morphology and behavior.

bioRxiv · May 12, 2020 · PreprintNeuroscience