Author

Lecia Van Dam Sequist

Massachusetts General HospitalORCID 0000-0002-8965-6991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. John Iafrate· 1 shared Aaron N. HataiD· 1 shared Benjamin Weinstein· 1 shared Brian B. LiauiD· 1 shared Çağrı ÇakiciiD· 1 shared Carmen Martin-AlonsoiD· 1 shared Cathy S. WangiD· 1 shared Chendi LiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. John Iafrate

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception

Cathy S. Wang, Qian Zhong, Shih‐Ting Wang, Carmen Martin-Alonso, Sofia Neaher, Sahil Patel, Tiziana Parisi, Jesse D. Kirkpatrick, Lecia Van Dam Sequist, Tyler Jacks, Sangeeta N. Bhatia

The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.

Science Advances · Aug 14, 2026Peer-reviewedBioengineering

Oxidized protein states define metastatic fitness in lung cancer

Maolin Ge, Magdy Gohar, Consuelo Torrini, Yukako Suzuki, Jiang, Yuchen Huang, Benjamin Weinstein, Janice Wong, Naema Nayyar, Md Yousuf Ali, Emily Sullivan, Stefan Andrew Harry, Çağrı Çakici, Zhuanglin Dai, Nicolò Vivori, , Liron Bar‐Peled

The paper identifies oxidative protein states as drivers of metastatic fitness in lung cancer by linking ROS-regulated protein modifications to mitochondrial function and metastasis.

bioRxiv · Jul 19, 2026 · PreprintCancer Biology