Increased CPT1a expression is a critical cardioprotective response to pathological stress that suppresses gene programs for remodeling and enables rescue by gene transfer
Andrew N. Carley, Santosh K. Maurya, Chandan Kumar Maurya, Yang Wang, Amy Webb, Azariyas A. Challa, Tatiana Gromova, Thomas M. Vondriska, Zhentao Zhang, Hua Zhu, Ahlke Heydemann, Kenneth C. Bedi, Christos P. Kyriakopoulos, Craig H. Selzman, Stavros George Drakos, , E. Douglas Lewandowski
This study shows that increased CPT1a expression protects the heart from pathological stress by suppressing harmful gene programs, and gene transfer can rescue cardiac function in disease models.
Circulation Research · Dec 4, 2025Peer-reviewedPhysiology