Lydia R. Heasley

The paper studies subtelomeric repeat amplifications in yeast, showing they impact fitness and cellular phenotypes by moving from neutral to deleterious effects.

This study identifies Awp11, an adhesin-like effector in Candida glabrata, as a key determinant of strain-dependent immunogenicity and gut colonization.

This study develops a computational model of aneuploid karyotype dynamics in budding yeast, revealing that reversion mechanisms vary by chromosome and can involve coupled nondisjunction and recombination.

The paper investigates how Big1 regulates cell size by controlling basal body number through cell cycle progression in Tetrahymena.

Middle school students isolated wild yeast from oak bark, sequenced HO alleles, and found limited HO diversity in North American oak isolates but high diversity in Kluyveromyces lactis.

The paper shows that stochastic genomic instability in yeast leads to phenotypic and genomic diversification through transient bursts of structural variations.

The paper presents a comprehensive genomic structural analysis of a pathogenic S. cerevisiae isolate using long-read sequencing, revealing extensive structural variation and its implications for genomic stability and development.

The paper identifies systemic aneuploidization events as the cause of phenotype switching in Saccharomyces cerevisiae, showing that stochastic chromosome copy number changes drive morphological variation.

The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.

This study investigates how aneuploidies arise in budding yeast, finding that loss of one chromosome often leads to additional unselected aneuploidies, resulting in complex genomic changes.