Ruth A. Watson

Candida glabrata replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability

This study shows that Candida glabrata replicating inside macrophages experiences amino acid deprivation, DNA damage, and chromosome instability, with mutations in RME1 enhancing its survival.

Formation of chromosomal rearrangements in Saccharomyces cerevisiae diploids through regionally-biased non-allelic homologous recombination

The paper identifies a bias for chromosomal rearrangements at the right arm of Chr7 in yeast, showing that this bias is due to inefficient repair rather than increased breakage.

Delineation of two multi-invasion-induced rearrangement pathways that differently affect genome stability

The paper identifies two distinct pathways of genome rearrangement induced by multi-invasion during homologous recombination and their impact on genome stability.

Characterization of systemic genomic instability in budding yeast

The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.

Punctuated Aneuploidization of the Budding Yeast Genome

This study investigates how aneuploidies arise in budding yeast, finding that loss of one chromosome often leads to additional unselected aneuploidies, resulting in complex genomic changes.